Abstract
Structure-activity relationship (SAR) studies of novel 2-[3-trifluoromethyl-5-alkyl(thio)ether pyrazo-1-yl]-5-methanesulfonyl pyridine derivatives for canine COX enzymes are described. The 4-cyano-5-alkyl ethers were found to have excellent potency and selectivity, whereas the 5-thioethers were potent but less selective than the ether analogs in a canine whole blood (CWB) COX-2 assay.
MeSH terms
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Alkylation
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Animals
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Cyclooxygenase 2 / metabolism*
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Cyclooxygenase 2 Inhibitors / chemical synthesis*
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Cyclooxygenase 2 Inhibitors / chemistry
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Cyclooxygenase 2 Inhibitors / pharmacokinetics
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Cyclooxygenase 2 Inhibitors / pharmacology*
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Dogs
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Ethers / chemistry*
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Inhibitory Concentration 50
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Molecular Structure
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Pyrazoles / chemistry*
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Structure-Activity Relationship
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Sulfhydryl Compounds / chemistry*
Substances
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Cyclooxygenase 2 Inhibitors
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Ethers
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Pyrazoles
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Sulfhydryl Compounds
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Cyclooxygenase 2